Journal
JOURNAL OF PEPTIDE SCIENCE
Volume 15, Issue 7, Pages 451-454Publisher
WILEY
DOI: 10.1002/psc.1141
Keywords
click reaction; Huisgen's cycloaddition; cyclopeptide; parathyroid hormone-related protein
Funding
- Fondazione Ente Cassa di Risparmio di Firenze
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Cu-I-catalyzed azide-alkyne 1,3-dipolar Huisgen's cycloaddition (CuAAC) is a click reaction that has drawn a lot of attention, in general, and in the field of peptide and protein sciences, in particular. Among several reported applications, the preparation of novel heterodetic cyclopeptides by an intramolecular side chain-to-side chain CuAAC, forming a 1,4-disubstituted[1,2,3]triazolyl-containing bridge, is of great interest. Herein, we provide a detailed protocol for the syntheses of model heterodetic cyclopeptides as a prototypical intramolecular CuAAC, using as a model a sequence derived from parathyroid hormone-related protein. Copyright (C) 2009 European Peptide Society and John Wiley & Sons, Ltd.
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