Journal
JOURNAL OF PEPTIDE SCIENCE
Volume 14, Issue 2, Pages 203-209Publisher
WILEY
DOI: 10.1002/psc.953
Keywords
peptide nanotube; antibody nanotube; crossbar; self-assembly; bionanotechnology; bottom-up; molecular recognition
Funding
- NCRR NIH HHS [G12 RR003037] Funding Source: Medline
- NIGMS NIH HHS [2-S06-GM-RR03037, S06 GM060654] Funding Source: Medline
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Previously, a large scale assembly of nanowires in a parallel array configuration has been demonstrated, and one type of nanowire could interconnect two electrodes in the high-wire density. However, to assemble nanowires into practical logic-gate configurations in integrated circuits, we need more than the parallel assembly of nanowires. For example, when the assembling nanowires are monopolar semiconductors, logic gates such as AND, OR and NOR are to be assembled necessarily from two types of semiconducting nanowires, n-type and p-type, and some of these nanowires must cross perpendicularly to form a crossbar geometry for the logical operation. In this paper, the crossbar assembly of antibody-functionalized peptide nanotubes was demonstrated by a new biomimetic bottom-up technique. Molecular recognition between antigens and antibodies enabled two types of the antibody-functionalized bionanotubes to place them onto targeted locations on substrates, where their complementary antigens were patterned. When two rectangular pads of antigens, human IgG and mouse IgG, were patterned perpendicularly on an Au substrate by nanolithography and then the antihuman IgG nanotubes and the antimouse IgG nanotubes were incubated on this substrate in solution, these bionanotubes were attached onto corresponding locations to form the crossbar configuration. Copyright (C) 2007 European Peptide Society and John Wiley & Sons, Ltd.
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