Journal
JOURNAL OF PEDIATRICS
Volume 158, Issue 3, Pages 442-446Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2010.08.046
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Funding
- American Diabetes Association [R01 DK 59211, M01 RR 00043]
- Mentor-Based Postdoctoral Fellowship [F31-DK081276]
- USC Center for Transdisciplinary Research on Energetics and Cancer [U54 CA 116848]
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Objective To examine changes in insulin sensitivity (SI), compensatory acute insulin response (AIR), and beta-cell function/disposition index (DI) across puberty in overweight Latino boys and girls. Study design Latino children (n = 253) were followed annually for up to 5 years. Longitudinal modeling was used to examine changes in SI, AIR, DI, and fasting and 2-hour glucose and insulin across Tanner stage. Results In boys, SI decreased in early puberty with a recovery by late puberty. The compensatory increase in AIR was appropriate in early maturation, but after Tanner stage 3, AIR declined by more than that predicted from the recovery in SI. For girls, SI decreased in early puberty and across all stages of maturation. In early maturation, there was an appropriate compensatory increase in AIR, but after Tanner stage 3, AIR decreased. Thus, DI deteriorated across puberty in boys and girls. Conclusions In overweight Hispanic youth, compensatory changes in insulin secretion fails after Tanner stage 3 in both sexes, indicating b-cell deterioration during this critical period of development, thus increasing risk for type 2 diabetes. (J Pediatr 2011;158:442-6).
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