Journal
JOURNAL OF PEDIATRICS
Volume 157, Issue 5, Pages 715-U39Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2010.04.032
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Funding
- Cambridge University Hospitals NHS Foundation Trust
- Novo Nordisk
- Medtronic
- Leeds General Infirmary research fund
- Clinicip Consortium
- University of Cambridge Department of Paediatrics
- NIHR Cambridge Biomedical Research Institute
- NHS Research and Development
- Medical Research Council [G0600717B, MC_U106179472] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10274] Funding Source: researchfish
- MRC [MC_U106179472] Funding Source: UKRI
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Objectives To investigate the prevalence and determinants of hyperglycemia in the preterm population, as part of the Neonatal Insulin Therapy in Europe (NIRTURE) Trial. Study design We conducted prospective cohort analyses of continuous glucose monitoring data from control infants participating in an international randomized controlled trial. Data were collected from 188 very low birth weight infants (< 1500 g). Results In the first week of life, 80% of infants had evidence of glucose levels > 8 mmol/L, and 32% had glucose levels > 10 mmol/L > 10% of the time. Independent risk factors for hyperglycemia included increasing prematurity, small size at birth, use of inotropes, lipid infusions, and sepsis. There was a lack of association between rate of dextrose infused and risk of hyperglycemia. Conclusion The prevalence of hyperglycemia in the very low birth weight infant is high, with marked variability in prevalence between infants, not simply related to rates of glucose infused, but to other potentially modifiable risk factors. (J Pediatr 2010; 157: 715-9).
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