Journal
JOURNAL OF PEDIATRICS
Volume 156, Issue 4, Pages 675-678Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2009.12.019
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- GlaxoSmithKline Biologicals, Rixensart, Belgium [105752]
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After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses. (J Pediatr 2010; 156: 675-8)
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