Journal
JOURNAL OF PEDIATRICS
Volume 155, Issue 5, Pages 714-720Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2009.05.031
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Funding
- NIH [NS32531]
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Objectives To study androgen treatment effects on arithmetic performance in girls with Turner syndrome. Study design Forty-four girls, ages 10 to 14 years at baseline, completed 4 years of treatment with oxandrolone (Ox) or placebo (PI). All received growth hormone and estrogen replacement therapy. We assessed the number of girls with severe learning disability (LD, standard score <= 5(th) percentile) on measures of academic arithmetic and reading achievement (WRAT-3, arithmetic and reading), given yearly, and the WIAT numerical operations (NOS) and reading subtests, given at year 4. Results On the WRAT-3 arithmetic, the frequency of severe arithmetic LD was similar in the Ox and PI groups at baseline and at years 1 and 2. At years 3 and 4, fewer girls in the Ox than PI group had a severe arithmetic LD (year 4: 0/22 vs 5/21, P = .02). On the WIAT NOS (year 4), fewer girls in the Ox than PI groups had a severe arithmetic LD (3/21 vs 8/20, P = .09). WIAT NOS error analysis suggested that the improved performance in the Ox group was associated with better performance on multiplication and division (P < .01). The frequency of severe LD for the WRAT-3 reading was similar for the Ox and PI groups (all years) and for the WIAT reading subtest (year 4). Conclusions Androgen treatment for 4 years in girls with Turner syndrome resulted in a small decrease in frequency of severe arithmetic LD, with no effect on reading LD. (J Pediatr 2009; 155: 714-20).
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