Journal
JOURNAL OF PEDIATRICS
Volume 153, Issue 6, Pages 864-866Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2008.06.015
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Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism. A prospective evaluation of 5 patients with Wilson's disease taking and not talking D-penicillamine for as long as 9.5 years showed subclinical hypothyroidism. D-penicillamine probably inhibited thyroperoxidase activity in utero in healthy infants and during childhood in patients with Wilson's disease. (J Pediatr 2008.153:864-6)
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