Journal
JOURNAL OF PEDIATRIC SURGERY
Volume 47, Issue 9, Pages E5-E7Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.jpedsurg.2012.04.019
Keywords
Osteosarcoma; Osteogenic sarcoma; Second primary; Neuroblastoma; Children
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Only 2 cases of osteosarcoma as a second primary malignancy after neuroblastoma have been reported in the literature. We present a case of chest wall osteosarcoma that developed in a 14-year-old boy 7 years after completion of chemotherapy, autologous peripheral blood stem cell transplantation, radiation, and resection for stage 3, high-risk neuroblastoma. A biopsy of a painful chest wall mass arising from the right third rib diagnosed osteosarcoma. He went on to have preoperative chemotherapy followed by wide local excision and chest wall reconstruction. He then received additional chemotherapy. This case highlights the importance of close observation for second malignancies in this patient population. (C) 2012 Elsevier Inc. All rights reserved.
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