Journal
JOURNAL OF PEDIATRIC SURGERY
Volume 44, Issue 8, Pages 1546-1551Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.jpedsurg.2008.10.109
Keywords
Gastroschisis; Omphalocele; Case-control; NBDPS; Birth defects
Categories
Funding
- Centers for Disease Control and Prevention (CDC) [3U50DD613236]
Ask authors/readers for more resources
Background: Primary prevention efforts for both gastroschisis and omphalocele are limited by the lack of known risk factors. Our objective was to investigate associations between potential maternal risk factors and gastroschisis and omphalocele within a large population-based sample of participants enrolled in the National Birth Defects Prevention Study (NBDPS). Methods: Demographic, health-related, and environmental exposure data from the NBDPS were collected from women with expected delivery dates between October 1997 and December 2003. Data were collected on 485 cases of gastroschisis, 168 cases of omphalocele, and 4967 controls. Results: Women who had offspring with gastroschisis were younger (adjusted odds ratio [AOR], 0.84; 95% confidence interval [Cl], 0.81-0.86) and less likely to be black (AOR, 0.54; 95% Cl, 0.34-0.85) than controls. They also were more likely to have smoked (AOR, 1.51; 95% Cl, 1.12-2.03), taken ibuprofen(AOR, 1.61; 95% Cl, 1.23-2.10), and consumed alcohol (AOR, 1.38; 95% Cl, 1.06-1.79)than controls. Women who had offspring with omphaloceles were more likely to have consumed alcohol (AOR, 1.53; 95% Cl, 1.04-2.25) and be heavy smokers (AOR, 4.26; 95% Cl, 1.58-11.52) than controls. Conclusions: Our results suggest a moderately increased risk of gastroschisis among women who used tobacco, alcohol, and ibuprofen during early pregnancy. A modestly elevated risk was observed for omphaloceles among women who used alcohol during the first trimester and among women who were heavy smokers. (C) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available