Journal
JOURNAL OF PEDIATRIC ONCOLOGY NURSING
Volume 30, Issue 2, Pages 63-77Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1043454212471728
Keywords
asparaginase; hypersensitivity; acute lymphoblastic leukemia; allergic reactions
Funding
- Sigma-Tau Pharmaceuticals, Inc.
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Hypersensitivity reactions to chemotherapeutic drugs have been documented for numerous cancer therapies. Clinical hypersensitivity to Escherichia coli asparaginase has been reported to range from 0% to 75%. Throughout the United States, nurses assume frontline responsibility for the assessment of asparaginase-related hypersensitivity reactions. It is essential that nurses educate themselves on the signs and symptoms of asparaginase-related hypersensitivity reactions as well as current supportive care approaches. The purpose of this review is to summarize acute lymphoblastic leukemia and the role of asparaginase and the pathology of allergic reactions. We will also update nurses on the differences in asparaginase preparations including dosing, half-life, rates of hypersensitivity, and routes of administration. A summary of current management and supportive care strategies will be provided as will a discussion of the relationship between allergy, antibodies, and asparaginase activity.
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