Journal
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
Volume 34, Issue 4, Pages E161-E163Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPH.0b013e318236c502
Keywords
cryptococcal; leukemia; pediatric; meningitis
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Funding
- NICHD NIH HHS [T32 HD043029, T32 HD060558] Funding Source: Medline
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Disseminated cryptococcal infection is rarely reported in the setting of pediatric acute leukemia, despite the immunocompromised state of these patients. However, when present, disseminated cryptococcal infection poses treatment challenges and is associated with significant morbidity and mortality. Treatment of invasive fungal disease in a child with acute leukemia requires a delicate balance between antifungal and antineoplastic therapy. This balance is particularly important early in the course of leukemia, as both the underlying disease and overwhelming infection can be life threatening. We describe the successful management of life-threatening disseminated cryptococcosis in a child with acute lymphoblastic leukemia during induction therapy.
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