Journal
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
Volume 46, Issue 1, Pages 80-83Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.mpg.0000304458.30294.31
Keywords
Prader-Willi syndrome; bariatric procedures; postoperative issues
Funding
- NICHD NIH HHS [P01 HD030329] Funding Source: Medline
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Prader-Willi syndrome (PWS) is a complex genetic disorder localized to chromosome 15 and is considered the most common genetic cause of the development of life-threatening obesity. Although some morbidities associated with PWS, including respiratory disturbance/hypoventilation, diabetes, and stroke, are commonly seen in obesity, others such as osteoporosis, growth hormone deficiency, and hypogonadism, and also altered pain threshold and inability to vonrit, pose unique issues. Various bariatric procedures have been used to cause gastric stasis, decrease gastric volume, and induce malabsorption, with poor results in PWS patients in comparison with normal obese individuals.
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