Journal
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Volume 27, Issue 7-8, Pages 769-771Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/jpem-2013-0305
Keywords
desmopressin; diabetes insipidus; preterm
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Background: As neonatal central diabetes insipidus is rare in preterm neonates with intraventricular hemorrhage (IVH), very little is known about dosing and the route of administration of desmopressin treatment. Case report: We present a preterm neonate born at 29 weeks' gestation. Within 24 h, she developed bilateral IVH with subsequent post-hemorrhagic hydrocephalus. On the 3rd postnatal day, she developed diabetes insipidus for which she was intranasally administered 0.2 mu g desmopressin. This resulted in oliguria with several hours of anuria and a 25-point drop in sodium levels within 15 h. Conclusion: The determination of the desmopressin dose in a preterm neonate is a challenge and there is no consistent literature about the dosing or the route of administration. We suggest starting with a low dose of intranasal desmopressin (0.05-0.1 mu g) and titrate in accordance with clinical and laboratory parameters.
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