Journal
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Volume 23, Issue 4, Pages 323-330Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/jpem.2010.052
Keywords
primary aldosteronism; endothelial injury; oxidative stress; arterial hypertension
Categories
Funding
- Fondecyt [1100356, 1070876]
- Becas-Chile
- Pontificia Universidad Catolica de Chila
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Aldosterone plays an important role in blood pressure homeostasis, the regulation of circulating volume, and the maintenance of the sodium-potassium balance by binding to the mineralocorticoid receptor (MR). Primary aldosteronism (PA) states are associated with an increased cardiovascular risk, mediated not only by hypertension but also by the action of aldosterone in the modulation of vasodilation / vasoconstriction and oxidative stress. In this review, we discuss some of the cardiovascular actions of aldosterone and the most frequent causes of PA.
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