Journal
JOURNAL OF PATHOLOGY
Volume 229, Issue 2, Pages 264-273Publisher
WILEY-BLACKWELL
DOI: 10.1002/path.4120
Keywords
fibrosis; epigenetics; methylation; CpG islands
Funding
- Deutsche Forschungsgemeinschaft [ZE523/2-1, SFB1002/TPC01]
- Else-Kroner Memorial Stipend [2005/59]
- University of Gottingen Medical Center
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The aberrant methylation of CpG island promoters of selected genes is the prominent epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant hypermethylation of a few selected genes plays an important role in facilitating fibrotic fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA methylation and demethylation and their implications for fibroblast activation and tissue fibrosis.Copyright (c) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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