Journal
JOURNAL OF PATHOLOGY
Volume 229, Issue 2, Pages 145-156Publisher
WILEY
DOI: 10.1002/path.4124
Keywords
acute respiratory distress syndrome; acute lung injury; pathogen recognition receptors; fibrosis; chemokines
Funding
- National Institutes of Health (NIH) [HL097564, HL25243]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL097564] Funding Source: NIH RePORTER
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Danger-associated molecular patterns (DAMPs) are host-derived molecules that can function to regulate the activation of pathogen recognition receptors (PRRs). These molecules play a critical role in modulating the lung injury response. DAMPs originate from multiple sources, including injured and dying cells, the extracellular matrix, or exist as immunomodulatory proteins within the airspace and interstitium. DAMPs can function as either toll-like receptor (TLR) agonists or antagonists, and can modulate both TLR and nod-like receptor (NLR) signalling cascades. Collectively, this diverse group of molecules may represent important therapeutic targets in the prevention and/or treatment of acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS).
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