Journal
JOURNAL OF PATHOLOGY
Volume 226, Issue 2, Pages 255-273Publisher
WILEY
DOI: 10.1002/path.3025
Keywords
cancer; cardiomyopathy; immunity; lysosomes; neurodegeneration; protein aggregation; proteolysis; proteotoxicity; T cell function
Funding
- National Institutes of Health/National Institute on Aging [AG021904, AG031782]
- National Institute of Allergy and Infectious Diseases [AI059738]
- Hirschl/Weill-Caulier Career Scientist Award
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI059738] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG021904, P01AG031782] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Autophagy is a process traditionally known to contribute to cellular cleaning through the removal of intracellular components in lysosomes. In recent years, intensive scrutiny at the molecular level to which autophagy has been subjected has also contributed to expanding our understanding of the physiological role of this pathway. Added to the well-characterized role in quality control, autophagy has proved to be important in the maintenance of cellular homeostasis and of the energetic balance, in cellular and tissue remodelling, and cellular defence against extracellular insults and pathogens. It is not a surprise that, in light of this growing number of physiological functions, connections between autophagic malfunction and human pathologies have also been strengthened. In this review, we focus on several pathological conditions associated with primary or secondary defects in autophagy and comment on a recurring theme for many of them, ie the fact that autophagy can often exert both beneficial and aggravating effects on the progression of disease. Elucidating the factors that determine the switch between these dual functions of autophagy in disease has become a priority when considering the potential therapeutic implications of the pharmacological modulation of autophagy in many of these pathological conditions. Copyright (C) 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available