Journal
JOURNAL OF PATHOLOGY
Volume 223, Issue 2, Pages 195-204Publisher
WILEY-BLACKWELL
DOI: 10.1002/path.2801
Keywords
metastasis; cancer stem cells; prognosis; tumour heterogeneity; microenvironment; genetics; epigenetics
Funding
- American Cancer Society
- Uniting Against Lung Cancer
- V Foundation
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Cancer metastasis is often considered an orderly sequence of events leading to the colonization of distal organs by malignant cells. In fact, the evolution of metastatic disease is a dynamic process that is influenced by unique cellular lineages, altered microenvironments, distinct anatomical restrictions and multiple genetic and epigenetic alterations. These factors all contribute to variable clinical courses, likely requiring tailored therapy. As we inch closer towards personalized medicine, there is a renewed conceptual and technological focus on characterizing the cellular and genetic heterogeneity within tumours, to ultimately trace the origins of metastatic cells in different cancers. Copyright (C) 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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