Journal
JOURNAL OF PATHOLOGY
Volume 217, Issue 2, Pages 161-168Publisher
WILEY
DOI: 10.1002/path.2442
Keywords
metaplasia; transdifferentiation; master regulatory gene; embryonic; development; pluripotent; stem cell
Funding
- MRC [G0300415, G0500220] Funding Source: UKRI
- Medical Research Council [G0300415, G0500220] Funding Source: Medline
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The nature and occurrence of metaplasia is briefly reviewed. A theory of how metaplasia is initiated is presented, depending on the idea that it represents an alteration in the combination of developmental transcription factors that are expressed. Two examples of experimental metaplasia, provoked by over-expression of specific transcription factors, are presented: the transformation of B lymphocytes to macrophages, and of pancreatic exocrine cells to hepatocytes. The formation of induced pluripotential stem cells (iPS cells) is considered an example of the same process, in which the destination state is the embryonic stem cell. It is noted that iPS cell production is a stochastic process, depending on selection to obtain the desired cell type. It is proposed that analogous technology, using the appropriate transcription factors, could be used to bring about transformation to cell types other than embryonic stem cells. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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