Journal
JOURNAL OF PATHOLOGY
Volume 215, Issue 3, Pages 211-213Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/path.2350
Keywords
chemokine; cancer; metastasis; CXCR4
Ask authors/readers for more resources
The evolutionarily conserved chemokine superfamily encodes small peptide molecules that bind G-protein-coupled receptors. In humans, this superfamily includes at least 46 ligands and 18 receptors. In general, chemokines and their receptors form a chemotactic network that regulates the migration of cells to specific micro-anatomical destinations within an organism in an organized and non-random manner. Recent studies place chemokine-chemokine receptor pairs at the centre of not only physiological cell migration, but also pathological processes such as metastasis. This mini review considers some recent data on how chemokines regulate tumour cells during metastasis. These observations suggest novel ways for pharmacological intervention. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available