Journal
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
Volume 38, Issue 2, Pages 197-207Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jpainsymman.2008.08.007
Keywords
Highly active antiretroviral therapy; symptoms; sex; race/ethnicity; aging
Funding
- NCRR NIH HHS [M01-RR-00083, M01 RR000722, M01-RR-00071, M01-RR-00079, M01 RR000079, M01 RR000052, M01 RR000071, 5-M01-RR-00052, 5-M01-RR-00425, M01 RR000083] Funding Source: Medline
- NIAID NIH HHS [U01 AI035004, U01 AI034993-14, U01 AI034989, U01 AI037613, U01-AI-35041, U01-AI-34994, U01 AI042590, U01 AI035042, U01-AI-34989, U01 AI034993, U01 AI035043, U01-AI-34993, U01 AI034994, U01 AI035043-17, U01-AI-42590, U01-AI-35042, U01-AI-35043, U01 AI037984, U01 AI035039, U01 AI035040, U01 AI031834, U01-AI-35039, U01-AI-37613, U01-AI-35004, U01-AI-37984, U01-AI-35040, U01 AI035041, U01-AI-31834, U01 AI042590-12] Funding Source: Medline
- NICHD NIH HHS [U01-HD-23632, U01 HD032632] Funding Source: Medline
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Few studies have evaluated age and racial/ethnic differences in the prevalence of symptoms in human immunodeficiency virus (H-Ill)-infected persons. Thus, the objective of this study was to compare the prevalence of gastrointestinal,, metabolic, general malaise, neurologic, or other self-reported symptoms by age and race/ethnicity among 1574 HIV-infiected women enrolled in the Women's Interagency HIV Study and 955 HIV-infiected men who have sex with men (MSM) enrolled in the Mullicenter-AIDS Cohort Study. All patients had known dales of initiation of highly active antiretroviral therapy. 11 was observed that, women aged 50 years or more were less likely to experience gastrointestinal symptoms (24% vs. 2 7%; multivariable P = 0.024), but more likely to experience general malaise (4 7% vs. 3 7 %; multivariable P = 0.004), neurologic (44 % vs. 38 %; multivariable P = 0.048), or other symptams (40 % vs. 28 %; multivariable P < 0.001) compared with women less than 40 years of age. Only neurologic symptoms had a higherprevalence among older MSM (52 % vs. 3 7 %; multivariable P = 0.002), largely driven by paresthesias (48 % vs. 31 %; multivariable P = 0. 004), the most common individual symptom. reported by men. Caucasian women generally had the highest prevalence of symptoms, and African A American women had the lowest prevalence. Few racial/ethnic difference were noted for MSM. Depression and a prior diagnosis of acquired immunodeficiency syndrome were. the strongest and most consistent predictors of clinical symptoms in both cohorts. In summary, the prevalence of reported symptoms varies with patient race/ethnicity, age, and modifiable factors, such as depression and HIV disease stage. Clinicians should. consider these factors when counseling patients regarding potential adverse effects of antiretrovirals or symptoms associated with HIV disease. J Pain Symptom Manage 2009;38:197-207. (C) 2009 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
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