4.4 Article

Topical Nifedipine for the Treatment of Localized Provoked Vulvodynia A Placebo-Controlled Study

Journal

JOURNAL OF PAIN
Volume 11, Issue 12, Pages 1403-1409

Publisher

CHURCHILL LIVINGSTONE
DOI: 10.1016/j.jpain.2010.03.016

Keywords

Vulvodynia; localized provoked vulvodynia nifedipine; chronic anal fissure; physical therapy

Funding

  1. Department of Obstetrics and Gynecology of Western Galilee Hospital Nahariya

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Topical application of the calcium antagonist nifedipine has demonstrated effectiveness in treating chronic anal fissure, without adverse effects Like chronic anal fissure, vulvodynia is associated with muscle hypertonicity and an inflammatory infiltrate We conducted a double-blind placebo-controlled study to investigate the effectiveness of 2 concentrations of topical nifedipine cream in the treatment of vulvodynia Thirty participants were alternately assigned to 3 topical treatment groups 2% nifedipine, 4% nifedipine, and placebo All administered the cream to the vestibule 4 times daily for 6 weeks For all 3 treatment groups, mean pain intensity on vestibular touch, assessed by the Q-tipped cotton test, pain from speculum insertion, and reports of pain during sexual intercourse was reduced at post-treatment compared with pre-treatment These improvements remained at 3 months follow-up The effectiveness of nifedipine in treating vulvodynia did not exceed that of placebo Perspective The topical application of both nifedipine and a placebo reduced pain in women with vulvodynia This study highlights the need for controlled trials of treatments for vulvodynia and raises doubts about studies conducted without comparison to placebo (C) 2010 by the American Pain Society

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