Journal
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
Volume 50, Issue 10, Pages E63-E67Publisher
WILEY
DOI: 10.1111/j.1440-1754.2010.01794.x
Keywords
congenital heart defects; enkephalin; hypoxia; opioid peptide; tetralogy of Fallot
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Funding
- National Health and Medical Research Council of Australia
- National Heart Foundation of Australia
- Alfred Hospital
- Cornelis Vrolijk Development Fund
- Dr Hendrik Muller Vaderlandsch Fonds
- Fundatie van de Vrijvrouwe van Renswoude
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Background: Cardiac opioid peptides have been identified to exert important adaptive metabolic signalling for cardioprotection against ischaemia or hypoxia-related injury. Aims: To determine myocardial methionine-enkephalin content in children with hypoxemic congenital heart defects and to correlate myocardial content of methionine-enkephalin with the extent of arterial oxygen desaturation. Methods: Children (n= 20, median age of 16 months), undergoing cardiac surgical repair (tetralogy of Fallot, 17/20), were included in this study. Arterial oxygen saturation was measured on admission. Myocardial samples obtained during surgery were assayed via radioimmunochemistry for methionine-enkephalin content. Results: Greater methionine-enkephalin content was measured in the right ventricles of the patients suffering from recent cyanotic spells compared with those with no recent spells (cyanotic spells: 2418 844 pg/g wet weight tissue, n= 6; no spells: 1175 +/- 189 pg/g wet weight tissue, n= 14, P= 0.04). An inverse correlation was evident between the arterial oxygen saturation and myocardial methionine-enkephalin content. Conclusion: Myocardial methionine-enkephalin levels increase with the severity of hypoxic stress in congenital cardiac disease and may play an important adaptive role in countering adrenergic over-activity and related excess demand on myocardial metabolic capacity.
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