Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 99, Issue 24, Pages 10539-10546Publisher
SPRINGER
DOI: 10.1007/s00253-015-6910-9
Keywords
Deinococcus radiodurans; Deinoxanthin; CYP287A1; Cytochrome P450; 2-beta-hydroxylase
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Funding
- National Basic Research (973) Program of China [2015CB755700]
- National High-Tech (863) Program of China [2012AA02A703]
- National Research and Development Project of Transgenic Crops of China [2014ZX08009-003]
- National Natural Science Foundation of China [31170105]
- US National Science Foundation [MCB-0948751]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0948751] Funding Source: National Science Foundation
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The carotenoid deinoxanthin is a crucial resistance factor against various stresses in the radiation-resistant bacterium Deinococcus radiodurans. Disruption of the gene dr2473 encoding the cytochrome P450 CYP287A1 led to the accumulation of 2-deoxydeinoxanthin in D. radiodurans, demonstrating that CYP287A1 is a novel beta-carotene 2-hydroxylase. The dr2473 knockout mutant was shown to be more sensitive to UV radiation and oxidative stress than the wild-type strain D. radiodurans R1, indicating that the C2 alcohol of deinoxanthin is important for antioxidant activity.
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