Journal
JOURNAL OF ORTHOPAEDIC TRAUMA
Volume 23, Issue 8, Pages 552-557Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BOT.0b013e3181a2e2b6
Keywords
negative pressure wound therapy; osteomyelitis; VAC; severe open fractures; orthopaedic trauma
Categories
Funding
- Kinetics Concepts, Inc, San Antonio, TX
Ask authors/readers for more resources
Objectives: To evaluate the impact of negative pressure wound therapy (NPWT) after severe open fractures on deep infection. Design: Prospective randomized study. Setting: Academic level I trauma center. Patients/Participants: Fifty-nine patients with 63 severe high-energy open fractures were enrolled in this study, with data available on 58 patients with 62 open fractures. Intervention: Twenty-three patients with 25 fractures randomized to the control group and underwent initial irrigation and debridement followed by standard fine mesh gauze dressing, with repeat irrigation and debridement every 48-72 hours until wound closure. Thirty-five patients randomized to the NPWT group and had identical treatment except that NPWT was applied to the wounds between irrigation and debridement procedures until closure. Main Outcome Measurements: The presence or absence of deep wound infection. or osteomyelitis, wound dehiscence, and fracture union were primary outcome measures. Results and Conclusions: Control patients developed 2 acute infections (8%) and 5 delayed infections (20%), for a total of 7 deep infections (28%), whereas NPWT patients developed 0 acute infections, 2 delayed infections (5.4%), for a total of 2 deep infections (5.4%). There is a significant difference between the groups for total infections (P = 0.024). The relative risk ratio is 0.199 (95% confidence interval: 0.045-0.874), suggesting that patients treated with NPWT were only one-fifth as likely to have an infection compared with patients randomized to the control group. NPWT represents a promising new therapy for severe open fractures after high-energy trauma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available