Journal
JOURNAL OF ORTHOPAEDIC RESEARCH
Volume 27, Issue 2, Pages 143-149Publisher
WILEY
DOI: 10.1002/jor.20723
Keywords
mechanical load; interstitial fluid flow; streaming potentials; osteocyte; osteoblast
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Funding
- National Institute on Aging [AG-13087]
- Penn State Tobacco Settlement Formula Fund
- Michael and Myrtle Baker Orthopaedic Research Endowment
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Mechanical loads are vital regulators of skeletal mass and architecture as evidenced by the increase in bone formation following the addition of exogenous loads and loss of bone mass following their removal. While our understanding of the molecular mechanisms by which bone cells perceive changes in their mechanical environment has increased rapidly in recent years, much remains to be learned. Here, we outline the effects of interstitial fluid flow, a potent biophysical signal induced by the deformation of skeletal tissue in response to applied loads, on bone cell behaviour. We focus on the molecular mechanisms by which bone cells are hypothesized to perceive interstitial fluid flow, the cell signaling cascades activated by fluid flow, and the used of this signal in tissue engineering protocols. (C) 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:143-149, 2009
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