Journal
JOURNAL OF ORTHOPAEDIC RESEARCH
Volume 27, Issue 1, Pages 84-90Publisher
WILEY
DOI: 10.1002/jor.20709
Keywords
cartilage detect; microfracturing; rabbit; small metal implant; osseointegration
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Funding
- Netherlands Organisation for Health Research and Development (NWO)
- Dutch Arthritis Association
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The purpose of the current study was to investigate the feasibility of the application of defect-size femoral implants in a rabbit model of established cartilage defects and compare this treatment to microfracturing. In 31 New Zealand White rabbits, a medial femoral condyle defect was created in each knee. After 4 weeks, 3 animals were killed for defect baseline values. In the other 28 rabbits, knees were sham-operated, treated with microfracturing, or treated by placing an oxidized zirconium (OxZr) or cobalt-chromium (CoCr) implant (V) articulating surface 3.5 min; fixating pin of 9.1 mm length). These aninials were sacrificed 4 weeks after treatment. Joints were evaluated macroscopically. Implant osseointegration was measured by automated histomorphometry, and cartilage repair was scored microscopically. Cartilage quality was analyzed macroscopically and microscopically. Bone-implant contact was 63.2% +/- 3.21% for CoCr and 62.5% +/- 3.2% for OxZr. Cartilage defects did not show complete healing, nor during subsequent sham-surgery or microfracturing. For all treatments, considerable cartilage damage in the articulating medial tibia, and degeneration of lateral tibial and femoral cartilage was observed (p < 0.05). Both CoCr and OxZr implant-treated defects showed an increase of cartilage degeneration compared to microfracturing and sham- defects (p < 0.05). Although only a single short-term follow-up period was investigated in this study, caution is warranted using small metal implants as a treatment for established localized cartilage defects because, even after 4 weeks in this model, the metal implants caused considerable degeneration of the articulating surface. (C) 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:84-90, 2009
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