4.5 Article

Air-stable and highly efficient indenyl-derived phosphine ligand: Application to Buchwald-Hartwig amination reactions

Journal

JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 706, Issue -, Pages 99-105

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2012.02.007

Keywords

Amination; Cross-coupling; Halide; Palladium; Phosphine

Funding

  1. National Natural Science Foundation of China [21072071]
  2. Science Foundation of Central China Normal University

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2-Mesitylindenyl phosphine ligand (1) and [(2-mesitylindenyl)dicyclohexyl-phosphine]PdCl2 (2) have been synthesized and fully characterized by NMR and elemental analysis, as well as by X-ray crystallography for 2. A Highly active catalyst system derived from a palladium precatalyst and bulky 2-mesitylindenyl phosphine ligand (1) for the Buchwald-Hartwig amination reaction of aryl halides with primary and secondary amines has been developed. This method allows for the preparation of a wide variety of amines in moderate to excellent yields and displays a high level of activity for the coupling of aryl chlorides as well as hindered aryl bromides. (C) 2012 Elsevier B. V. All rights reserved.

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