4.5 Article

A ruthenium-catalyzed coupling of alkynes with 1,3-diketones

Journal

JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 716, Issue -, Pages 6-10

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2012.05.017

Keywords

Alkynes; Ene reaction; Homogeneous catalysis; Ruthenium

Funding

  1. University of Southern California
  2. Hydrocarbon Research Foundation
  3. National Science Foundation [CHE-1054910, DBI-0821671, CHE-0840366]
  4. USC Provost Fellowship
  5. USC College Doctoral Fellowship
  6. NIH [S10-RR25432]
  7. Direct For Mathematical & Physical Scien
  8. Division Of Chemistry [1054910] Funding Source: National Science Foundation

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Ruthenium(III) chloride hydrate is a convenient catalyst for the addition of active methylene compounds to aryl alkynes. These reactions are rapid, operationally simple, and high yielding in cases. Most significantly, no precautions are required to exclude air or water from the reactions. All reagents are commercially available at reasonable prices, and the reactions can be conducted in disposable glassware with minimal solvent. (C) 2012 Elsevier B.V. All rights reserved.

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