4.5 Article

Nickel-catalyzed, base-mediated amination/hydroamination reaction sequence for a modular synthesis of indoles

Journal

JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 696, Issue 1, Pages 195-201

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2010.08.047

Keywords

Amination; Base; Hydroamination; Indole; Nickel

Funding

  1. DFG
  2. Chinese Scholarship Council

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A catalytic system consisting of [Ni(cod)(2)] and ligand dppf enabled an efficient synthesis of differently substituted indoles through a modular reaction sequence, which consists of intermolecular aminations and intramolecular hydroaminations with ortho-alkynylhaloarenes. (C) 2010 Elsevier B.V. All rights reserved.

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