Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 696, Issue 5, Pages 999-1010Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2010.11.010
Keywords
Bioinorganic chemistry; Bioorganometallic chemistry; Medicinal chemistry; Metal complexes; (Thio)pyr(id)one ligands
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Funding
- Johanna Mahlke geb. Obermann-Stiftung
- Higher Education Commission of Pakistan
- Austrian Exchange Service (AD)
- Hochschuljubilaumsstiftung Vienna
- FFG - Austrian Research Promotion Agency [811591]
- Austrian Council for Research and Technology Development [IS526001, COST D39, CM0902]
- Austrian Science Fund
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Pyrone scaffolds are often present in natural products and many derivatives therefore exhibit favorable biocompatibility and toxicity profiles. Hydroxypyrones are obtained from natural sources or can be synthesized by different well established approaches and may easily be converted into the analogous thiopyrones and hydroxypyridones. These features make them well suited to drug development and other biological applications. Herein, we summarize recent literature on the use of (thio)pyr(id) ones in bioinorganic chemistry with a focus on their metal ion chelating properties. Selected examples and different approaches using (thio)pyr(id) ones are presented and the influence of structural modifications on their chemical, physical and biological properties are discussed. (C) 2010 Elsevier B. V. All rights reserved.
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