Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 696, Issue 5, Pages 1066-1071Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2010.10.054
Keywords
Gold; Silver; N-Heterocyclic carbene; Transmetallation; Anticancer agent
Categories
Funding
- The Ohio State University
- The University of Akron
- The University of Akron Center for Silver Therapeutic Research
- Ohio Board of Regents
- National Institutes of Allergies and Infectious Diseases [1 R01 A106785601]
- National Science Foundation [CHE-0341701, DMR-0414599, CHE-0116041]
Ask authors/readers for more resources
Bis(1,3-dimethylimidazol-2-ylidene)silver(I) nitrate and bis(4,5-dichloro-1,3-dimethylimidazol-2-ylidene) silver(I) nitrate were prepared by reacting the corresponding imidazolium nitrate salts with silver oxide. Bis(1,3-dimethylimidazol-2-ylidene) gold(I) nitrate and bis(4,5-dichloro-1,3-dimethylimidazol-2-ylidene) gold(I) nitrate salts were prepared via transmetallation of their silver precursors with chloro dimethylsulfide gold. The anticancer properties were determined using NCI-H460 lung cancer cells. Efficacy was established by comparison of the gold and silver compounds with cisplatin. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available