Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 696, Issue 5, Pages 1066-1071Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2010.10.054
Keywords
Gold; Silver; N-Heterocyclic carbene; Transmetallation; Anticancer agent
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Funding
- The Ohio State University
- The University of Akron
- The University of Akron Center for Silver Therapeutic Research
- Ohio Board of Regents
- National Institutes of Allergies and Infectious Diseases [1 R01 A106785601]
- National Science Foundation [CHE-0341701, DMR-0414599, CHE-0116041]
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Bis(1,3-dimethylimidazol-2-ylidene)silver(I) nitrate and bis(4,5-dichloro-1,3-dimethylimidazol-2-ylidene) silver(I) nitrate were prepared by reacting the corresponding imidazolium nitrate salts with silver oxide. Bis(1,3-dimethylimidazol-2-ylidene) gold(I) nitrate and bis(4,5-dichloro-1,3-dimethylimidazol-2-ylidene) gold(I) nitrate salts were prepared via transmetallation of their silver precursors with chloro dimethylsulfide gold. The anticancer properties were determined using NCI-H460 lung cancer cells. Efficacy was established by comparison of the gold and silver compounds with cisplatin. (C) 2010 Elsevier Ltd. All rights reserved.
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