Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 695, Issue 8, Pages 1189-1199Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2010.01.024
Keywords
Schiff-bases; Sn-119 NMR; Organotin compounds; Amino acids; Cancer cell lines; Crystal structure
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Funding
- CONACyT
- UNAM [PAPIIT IN-214010, PAPIIT IN-202708]
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In this work we report the synthesis and spectroscopic characterization of twenty new pentacoordinated diorganotin(IV) compounds. These compounds have been prepared in good yields by multicomponent reactions (MCRs) of alpha-amino acids (isoleucine, leucine, methionine, phenylalanine and aminophenylacetic acid), 2,4-dihydroxybenzaldehyde, 2-hydroxy-4-methoxybenzaldehyde and either di-n-butyltin(IV) oxide or diphenyltin(IV) oxide. All compounds were characterized by IR spectroscopy, H-1, Sn-119 and C-13 NMR spectroscopy and mass spectrometry. Each compound has a coordinative N -> Sn bond and shows the expected Sn-119 NMR chemical shift indicative of a pentacoordinated or hexacoordinated tin atom in CDCl3 and DMSO-d(6), respectively. These compounds were also tested in tumoral cell lines, HeLa, HCT-15 and MCF-7, in order to evaluate the antiproliferative activity and to obtain the medial inhibitory concentrations (IC50) values. (C) 2010 Elsevier B.V. All rights reserved.
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