Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 694, Issue 25, Pages 4069-4075Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2009.08.024
Keywords
6-hydroxy chromone-3-carbaldehyde thiosemicarbazone; Ni(II) complex; Crystal structure; DNA binding; Cytotoxic activity
Categories
Funding
- National Natural Science Foundation of China [20475023]
Ask authors/readers for more resources
A new ligand L, 6-hydroxy chromone-3-carbaldehyde thiosemicarbazone, and its Ni(II) complex have been synthesized and characterized. The crystal structure of Ni(II) complex was determined by single crystal X-ray diffraction. Ni(II) complex and ligand L were subjected to biological tests in vitro using THP-1, Raji and Hela cancer cell lines. Compared with the ligand, Ni(II) complex showed significant cytotoxic activity against these three cancer cell lines. The interactions of Ni(II) complex and ligand L with calf thymus DNA were then investigated by spectrometric titration, ethidium bromide displacement experiments and viscosity measurements methods. The experimental results indicated that Ni(II) complex bound to DNA by intercalative mode via the ligand L. The intrinsic binding constants of Ni(II) complex and ligand L with DNA were (1.10 +/- 0.65) x 10(6) M-1 and (1.48 +/- 0.57) x 10(5) M-1, respectively. (C) 2009 Elsevier B. V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available