Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 694, Issue 21, Pages 3431-3437Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2009.06.036
Keywords
Organotin; Crystal structures; Intercalation; Prostate cell lines (PC-3)
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Funding
- Higher Education Commission of Pakistan
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Four new organotin(IV) carboxylates, [Bu2SnL2] (1), [Et2SnL2] (2), [Bu3SnL](n) (3), [Me3SnL](n) (4), where L = 4-nitrophenylethanoates, were synthesized and characterized by elemental analysis, FT-IR and multinuclear NMR (H-1 and C-13). Spectroscopic results authenticated the coordination of ligand to the organotin moiety via COO group while X-ray single crystal analysis revealed bidentate chelating mode of coordination of ligand in complex 2 and a bridging behavior in complexes 3 and 4. Cyclic voltammetric ( CV) technique was used to evaluate the electrochemical, kinetic and thermodynamic parameters of complexes 1-4, interacting with DNA. The linearity of the plots between the peak current (I) and the square root of the scan rate (nu(1/2)) indicated the electrochemical processes to be diffusion controlled. The diffusion coefficients of the free (D-f) and DNA bound forms (D-b), standard rate constants (ks) and charge transfer coefficients (alpha) were determined by the application of Randle-Sevcik, Nicholson and Kochi equations. Furthermore, the binding constants evaluated from voltammetric data revealed the following increasing order of binding strength: 2 < 1 < 4 < 3. For 1 and 2, the activity against prostate cancer cell lines (PC-3) was found consistent with the order obtained from voltammetric behavior. (C) 2009 Elsevier B.V. All rights reserved.
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