Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 19, Pages 12239-12246Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b01632
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Funding
- JSPS [17K05867, 18K14225]
- Japan Scientific Society [2018-3015]
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A synthesis of chiral homoallylic nitriles by the iridium-catalyzed allylation of cyanoacetates followed by Krapcho demethoxycarbonylation has been developed. A wide range of homoallylic nitriles were obtained with a high enantioselectivity (>95-99% ee). These compounds are useful chiral building blocks because further synthetic elaboration starting from a nitrile or terminal alkene is possible.
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