Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 19, Pages 12184-12191Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b00586
Keywords
-
Categories
Funding
- Ministry of Science and Technology of Republic of China [102-2113-M-003-006-MY2, 104-2628-M-003-001-MY3]
- National Taiwan Normal University (NTNU 2016 Subsidy Policy for International Collaboration and Research Projects)
Ask authors/readers for more resources
The highly enantioselective conjugate addition of a variety of arylboronic acids to beta-nitroacrylates is reported to provide optically active alpha-aryl beta-nitropropionates in up to 70% yields and >99.5% ee's, which are useful building blocks for preparing chiral beta(2)-amino acids. The applicability of this transformation is demonstrated by converting 3aa into the beta(2)-amino acid 5 and transforming 3ap to beta-amino ester 7 via reduction and reductive N-alkylation. The latter compound is a precursor for preparing ent-ipatasertib.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available