Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 17, Pages 10352-10358Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b01460
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Funding
- National Natural Science Foundation of China [21372035, 21572028]
- Liaoning Natural Science Foundation of China [201602181]
- Outstanding Young Scholars Development Growth Plan of universities in the Liaoning Province [LJQ2015027]
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This paper describes a convenient method to synthesize quinazolin-4(3H)-ones from simple and readily available 2-halobenzamides and nitriles. The Lewis acid Cu-catalyzed nucleophilic addition of 2-halobenzamide to nitriles followed by SNAr reaction proceeds smoothly in the presence of (BuOK)-Bu-t as a base to produce quinazolinone derivatives.
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