4.7 Article

One-Pot Synthesis of 1,4-Disubstituted Pyrazoles from Arylglycines via Copper-Catalyzed Sydnone-Alkyne Cycloaddition Reaction

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 16, Pages 7772-7777

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo501420r

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Funding

  1. ANR (ClickScreen project)
  2. labex Charmmmat

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A robust method for constructing 1,4-pyrazoles from arylglycines was developed using the copper-catalyzed sydnone-alkyne cycloaddition reaction. The procedure offers a straightforward and general route to the pyrazole heterocycle through a three-step one-pot procedure.

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