4.7 Article

Metal-Free TEMPO-Promoted C(sp3)-H Amination To Afford Multisubstituted Benzimidazoles

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 10, Pages 4727-4734

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo5005179

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Funding

  1. National Natural Science Foundation of China [81123004, 81325020, 81361120410]

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An efficient TEMPO-air/cat. TEMPO-O-2 oxidative protocol was developed to synthesize multisubstituted or fused tetracyclic benzimidazoles via a metal-free oxidative C-N coupling between the sp(3) C-H and free N-H of readily available N-1-benzyl/alkyl-1,2-phenylenediamines.

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