Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 21, Pages 10655-10661Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo501991s
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- Spanish Ministerio de Economia y Competitividad (MICINN)
- European Regional Development Fund [CTQ2011-28417-C02-02]
- Spanish MEC
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A general and practical metal-free protocol for the synthesis of 1,2-dihydropyridines with wide structural/functional diversity at the ring and featuring mono, double, or spiro substitution at the sp(3) position is described. The protocol entails a microwave-assisted domino reaction of a propargyl vinyl ether (secondary or tertiary) and a primary amine (aliphatic or aromatic) in toluene or methanol
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