Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 16, Pages 7512-7519Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo501225y
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The first enantioselective total synthesis of penostatin E has been accomplished. Two highly efficient and diastereoselective reactions, a Hosomi-Sakurai allylation and an intramolecular Pauson-Khand reaction, were utilized for the construction of the basic carbon framework of the target molecule as the key steps. A late-stage introduction of the side chain and a successful base-promoted elimination reaction afforded an efficient synthetic route to (+)-penostatin E.
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