Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 14, Pages 6759-6764Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo501255c
Keywords
-
Categories
Funding
- Australian Research Council
- Institute of Advanced Studies
- CSC Ph.D. scholarship by the Government of the People's Republic of China
Ask authors/readers for more resources
The 1,9-ethanoiminomethano-bridged tetrahydrodibenzo[b,d]-furan 2, a non-natural isomer of the alkaloid (-)-galanthamine (1) varying in the manner in which the D-ring is annulated to the ABC-core, has been prepared in racemic form. The synthetic sequence starts with the cyclopropane 3 and involves intramolecular Heck alkenylation and radical-based Smiles rearrangement reactions as key steps. Unlike natural product 1, but as predicted by docking studies, compound 2 is not a potent inhibitor of acetylcholine esterase.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available