4.7 Article

Regioselective and Guided C-H Activation of 4-Nitropyrazoles

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 7, Pages 2906-2915

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo4025418

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Funding

  1. DAAD
  2. State of Mecklenburg-Vorpommern
  3. Enamine Ltd. Company (Ukraine)

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A divergent and regioselective approach to 5-aryl-4-nitro-1H-pyrazoles was developed by guided transition-metal-catalyzed arylation of 4-nitro-1H-pyrazoles. This method provides a convenient tool for the functionalization of the pharmacologically relevant pyrazole scaffold. The scope and limitations of the methodology were studied.

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