Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 6, Pages 2792-2802Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo5002627
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Funding
- Ministry of Economy and Competitiveness, Spain [CTQ2012-35250]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya [2009SGR-1111]
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LiNH2BH3-promoted reductive opening of 8-substituted phenylglycinol-derived oxazolopiperidone lactams leads to enantiopure 4-substituted-5-aminopentanols, which are used as starting building blocks in the synthesis of the Haliclona alkaloids haliclorensin C, haliclorensin, and halitulin (formal). The starting lactams are easily accessible by a cyclocondensation reaction of (R)-phenylglycinol with racemic gamma-subtituted delta-oxoesters, in a process that involves a dynamic kinetic resolution.
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