4.7 Article

Synthesis of Optically Active Deuterated Primary Amines via Reduction of N-tert-Butanesulfinyl Aldimines

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 17, Pages 8417-8421

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo500767k

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Funding

  1. National Basic Research Program of China (973 program) [2010CB833300]
  2. Chinese Academy of Sciences

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Optically active deuterated primary amines have been obtained with 78-98% ee's from chiral N-tert-butanesulfinyl aldimines via reduction with N-Selectride and subsequent alcoholysis.

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