4.7 Article

Synthesis of the Erythrina Alkaloid Erysotramidine

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 17, Pages 8481-8485

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo501583c

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Funding

  1. Natural Sciences and Engineering Research Council of Canada (NSERC)
  2. Canada Foundation for Innovation (CFI)
  3. provincial government of Quebec (FQRNT)
  4. provincial government of Quebec (CCVC)

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A concise synthesis of erysotramidine (an alkaloid belonging to the erythrina family) was achieved starting with an inexpensive phenol and amine derivative. The synthesis is based on oxidative phenol dearomatizations mediated by a hypervalent iodine reagent and includes a novel route to a key indolinone moiety.

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