4.7 Article

Thiourea-Based Fluorescent Chemosensors for Aqueous Metal Ion Detection and Cellular Imaging

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 13, Pages 6054-6060

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo500710g

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Funding

  1. Swiss National Science Foundation
  2. Institute of Organic Chemistry (UZH)
  3. GlaxoSmithKline

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We describe three significant advances in the use of thioureas as reporting elements for metal-responsive fluorescent chemosensors. First, on the basis of the crystal structure of a chemosensor analogue, we provide a deeper understanding of the details of the thiourea coordination environment. Second, we describe a new generation of chemosensors with higher affinities for Zn2+ and Cd2+ than were observed for earlier probes, expanding the scope of this type of probe beyond Hg2+ detection. Third, we show that a thiourea-based chemosensor can be employed for fluorescence microscopy imaging of Hg2+ ion concentrations in living mammalian cells.

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