Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 22, Pages 11285-11289Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo502204a
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Funding
- National Natural Science Foundation of China [21272028, 21202013]
- Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]
- Changzhou University
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A tert-butyl peroxybenzoate (TBPB)-promoted direct a-methylation of 1,3-dicarbonyl compounds has been developed, providing alpha-methyl derivatives in moderate to good yields. In this procedure, TBPB plays a dual role, serving as both the methyl source and radical initiator. This work represents a key complement to the traditional alpha-methylation of 1,3-dicarbonyl compounds using methyl iodide.
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