Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 16, Pages 7399-7404Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo501119f
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Funding
- Ranbaxy Laboratories of India
- UGC, New Delhi, India
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A straightforward method has been developed for the synthesis of aroyl-substituted imidazo-/benzimidazo-fused isoquinolines. The cascade reaction proceeds via a cross-aldol condensation of 2-(1H-imidazol-1-yl/benzimidazolyl-1-yl)-1-arylethanones and 2-bromobenzaldehyde followed by palladium-catalyzed intramolecular C-H fiinctionalization. This approach offers a simple and efficient alternative one-pot protocol for the assembly of imidazo/benzimidazo[2,1-a]isoquinolines in moderate to good yields.
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